The study consisted of an analysis of 44,000 cells obtained from autopsied human testes samples from four young men and eight older men. Bradley Cairns, of the University of Utah School of Medicine, said: 'Aging may confer a combination of modest molecular changes that sensitize the testis for additional dysregulation, with pronounced dysregulation caused when aging is combined with additional factors such as obesity.' Researchers say the results reveal that while ageing may lead to weaker sperm overall, having a high BMI exacerbates the process.ĭr. 'It also serves as a foundational dataset for the scientific community to study how human testis and fertility respond to ageing.” Jingtao Guo, also of the University of Utah School of Medicine, said: 'Our study reveals potential biomarkers for diagnosis of testis aging and directions for potential treatment of aging-related subfertility. The research was published in the journal Developmental Cell. Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
